Department of Pharmaceutical Microbiology and Biotechnology
Pharmaceutical Microbiology and Biotechnology
- Details
- Published: 12 February 2019
Name of Department: Department of Pharmaceutical Microbiology and Biotechnology
Name of Ag.Head Of Deparment: Dr. Chidozie N. E. Ibezim
Contact E-mail: chidozie.ibezimThis email address is being protected from spambots. You need JavaScript enabled to view it.
Contact Phone Number(s): 08033835299
COURSE DESCRIPTION FOR PHARMACEUTICAL MICROBIOLOGY & BIOTECHNOLOGY
YEAR TWO SECOND SEMESTER
PMB 241.2: Introduction to Pharmaceutical Microbiology 3 Units
Historical development of microbiology, scope and its relevance to Pharmacy – Micro-organism and medicine; the discovery of micro-organisms; the role of micro-organisms in disease; the scope and relevance of Pharmaceutical microbiology; the future of Pharmaceutical microbiology.
Study of Microbial Structures – Microscopy; specimen preparations.
Presence and effects of micro-organisms on the environment – ubiquity; characteristics.
The viruses – General characteristics; human viruses (important human viruses and their properties); multiplication of human viruses; cultivation of viruses; purification and assay of viruses;
Bacterial cells – Cell structures; classification; properties; metabolism; nutrition; growth; factors influencing their growth; enumeration; identification; diseases; mechanisms of pathogenicity.
Fungal cells – Cell structures; classification; properties; metabolism; nutrition; growth; factors influencing their growth; enumeration; identification; diseases; mechanisms of pathogenicity.
Protozoa – Cell structures; classification; properties; metabolism; nutrition; growth; factors influencing their growth; enumeration; identification; diseases; mechanisms of pathogenicity.
Helminths – Cell structures; classification; properties; metabolism; nutrition; growth; factors influencing their growth; enumeration; identification; diseases; mechanisms of pathogenicity.
PMB 242.2: Practical Pharmaceutical Microbiolog I 1 Unit
Laboratory experiments to demonstrate some basic pharmaceutical microbiological principles and techniques. Isolation and characterization of common opportunistic and pathogenic microorganisms as well as other techniques used in the diagnosis of infectious diseases.
YEAR THREE FIRST SEMESTER
PMB 341.1: Pharmaceutical Microbiology II 3 Units
Antimicrobial agents as disinfectants, antiseptics and preservatives – Definitions; types; properties; factors affecting activities of antimicrobial agents; evaluation of the activity of such antimicrobial agents.
Evaluation of microbial contents of pharmaceutical preparations and products.
Microbial spoilage of pharmaceutical preparations - Spoilage (pharmaceutical ingredients susceptible to microbial attack, effect of microbial attack on Pharmaceutical products, factors affecting microbial spoilage of Pharmaceutical products); hazard to health; sources and control of contamination
Aseptic techniques - Principles and processes
Sterilization - Principles and processes; sterilization methods, etc.
Sterile preparations - Types of sterile products; quality control and quality assurance of sterile products (bioburden, sterility, pyrogen,
Industrial uses of micro-organisms - Production of solvents, antibiotics, steroids.
Good manufacturing practice (GMP).
Environmental Microbiology
PMB 342.1: Practical Pharmaceutical Microbiology II 1 Unit
Practical exposure for topics covered in PMB 341.1. such as the basic principles and procedures for preparing sterile products, the preparation of water for injection, small volume injections, eye drops, eye lotions, intravenous fluids and bacterial vaccines. Sterilization and disinfection, sterility testing, etc.
YEAR FOUR FIRST SEMESTER
PMB 441.1: Microbial Chemotherapy 2 Units
Anti-infectives and chemotherapeutic agents – Definitions; sources; types of antibiotics – antibacterials; antifungals; antivirals; antiprotozoal.
Microbial genetics – Replication, transcription, translation, gene expression and genetic variation
Mechanism of action of antibiotics – Inhibitors of cell wall synthesis; inhibitors of protein synthesis; inhibitors of nucleic acid synthesis; inhibitors of metabolic pathway etc.
Antimicrobial resistance - mechanism of resistance; drug resistance; multi-drug resistance; causes of resistance; consequences of resistance; prevention of resistance.
Evaluation of antimicrobial activities and antibiotic assays – sensitivity and resistance testing; broth dilution method; agar dilution method; disc diffusion method, ditch diffusion method; combination assays
PMB 442.1: Practical Pharmaceutical Microbiology III 1 Unit
To provide practical exposure for topics covered in PMB 441.1. The methods used for microbiological assay of antibacterial agents, antifungal agents, etc. The evaluation of the activity of antimicrobial agents; evaluation of microbial contents of pharmaceutical preparations, products and processes.
YEAR FOUR SECOND SEMESTER
PMB 443.2: Parasitology 2 Unit
Basic parasitology - Host-parasite relationship
Classification of parasitic organisms
Pathogenesis, Morphology, identification and treatment of blood and tissue protozoans such as Plasmodium species, trypanosoma species, Leishmania species.
Pathogenesis, Morphology, identification and treatment of intestinal protozoans such as Entamoeba histolytica; Giardia lamblia, urogenital protozoans such as Trichomonas vaginalis
Pathogenesis, Morphology, identification and treatment of helminths (intestinal helminths – roundworm, threadworms, hookworm, tapeworm, strongloidiasis, whipworm,etc)
Pathogenesis, Morphology, identification and treatment of helminths (tissue or visceral helminths – filariasis, Schistosomiasis, etc.
Veterinary parasites and control systems
YEAR FIVE FIRST SEMESTER
PMB 541.1: Immunology and Clinical Microbiology 2 Units
Overview of immunology, Mechanisms of disease pathogenicity, Clinical presentations of infectious diseases, Control of infection in the hospital and community
Microbial diseases discussed under the following sub-headings – definition; aetiological agent; pathogenesis; epidemiology; modes of transmission; symptoms and clinical presentations; lab diagnosis; treatment; prevention; the problem of chemotherapy.
Upper respiratory tract infections: sinusitis; tonsillitis; otitis media; rhinitis
Lower respiratory tract infections – pneumonia; tuberculosis; diphtheria; legionella; bronchitis
Gastrointestinal tract infections – typhoid fever; gastroenteritis
Skin and soft tissue infections – acne, folliculitis, carbuncle, skin abscess
CNS infections – meningitis
Blood infections - septicaemia
Urinary tract infections – uncomplicated UTI (cystitis); complicated UTI(pyelonephritis)
Sexually transmitted diseases – pelvic inflammatory disease, gonorrhea, syphilis, Chlamydia
Fungal diseases – candidiasis, cutaneous mycosis, subcutaneous mycosis; systemic mycosis; opportunistic mycosis
Viral diseases – HIV/AIDS; herpes simplex; hepatitis, common cold; rabies; measles, problems of viral chemotherapy etc
YEAR FIVE SECOND SEMESTER
PMB 542.2: Immunology and Biotechnology 2 Units
Introductory Immunology – Definition of terms: Immunity, antigens, antibodies, their reactions and applications,
Immune response – Specific (acquired) and non-specific (innate) immune response
Monoclonal antibodies – production and application;
Serological reactions – diagnostic, pharmaceutical and medical applications of serological reactions;
Hypersensitivity reactions – causes and types
Immune diseases – HIV/AIDS; autoimmune diseases e.g. rheumatoid arthritis; asthma
Tissue transplantation.
Blood and blood products - Properties and uses of whole blood and fractions; preservation of whole blood and blood fraction.
Immunological products – vaccines, immunosera – Production and quality control.
Immunological products – human immunoglobulins, in-vivo diagnostics – production and quality control.
Introduction to biotechnology
DNA, RNA, protein extraction techniques; stabilization and purification techniques
Analytical techniques – page and blotting techniques and immunoassays
Gene cloning
Polymerase chain reaction (PCR)
PHA 501.2: Project 6 Units
Each student is expected to carry out research project supervised by an academic staff. Such project will be assigned at the beginning of the final year (500 level). The research result is presented, bound for grading after a project seminar presented by each student.
